Ibogaine Treatment for Oxycodone Addiction

Oxycodone is one of the most powerful and widely prescribed semi-synthetic opioids in the world. Originally formulated to provide sustained pain relief, it alters the brain’s chemistry by binding to mu-opioid receptors, blocking pain signals, and flooding the brain with dopamine.

However, this temporary relief often comes at a devastating cost. Physical dependence on oxycodone can develop in a matter of weeks. When the prescription runs out—or when tolerance forces the user to seek higher doses—the brain’s natural ability to produce endorphins and regulate dopamine is severely compromised. The resulting withdrawal symptoms (bone pain, severe anxiety, restless legs, and insomnia) are so agonizing that many individuals remain trapped in a cycle of addiction simply to avoid the sickness.

Traditional detox programs rely heavily on maintenance medications like Suboxone or Methadone, which effectively substitute one opioid for another. At Ibogaine By David Dardashti, we offer a profound alternative: a medically supervised, 8-to-10-day ibogaine protocol designed to eliminate oxycodone withdrawals, interrupt cravings, and restore your neurochemistry.

The 8-10 Day Oxycodone Protocol

Oxycodone’s half-life and the severity of its physical withdrawals require a highly structured, multi-dose approach. Our medical team utilizes a precise 8-to-10-day protocol to ensure a safe, comfortable, and complete detoxification.

1. Stabilization and Assessment (Days 1-2)

Upon arrival at our Playa del Carmen clinic, you will undergo comprehensive medical testing, including EKGs, blood work, and psychological evaluations. You will be stabilized using short-acting medications to ensure you are comfortable and physically prepared for the ibogaine.

2. The First Flood Dose (Day 3)

The initial “flood dose” of ibogaine is administered under continuous EKG and cardiac monitoring. This primary dose is designed to act rapidly on the brain’s opioid receptors. Within 45 to 60 minutes, physical withdrawal symptoms begin to vanish. During the visionary phase of this dose (which lasts 6 to 12 hours), the NMDA receptors are modulated, allowing you to confront and process the root causes or traumas tied to your addiction without emotional distress.

3. The Second Flood Dose (Day 5 or 6)

Because oxycodone alters receptor density so severely, a single dose is rarely enough for heavy, long-term users. The second flood dose ensures that all residual withdrawal symptoms are eradicated, and the brain’s serotonin and dopamine pathways are fully flushed and reset.

4. Booster Treatments

Throughout your stay, our medical staff will administer two targeted booster doses of ibogaine. These smaller doses help to prolong the “afterglow” effect—saturating the fat tissues with noribogaine (the long-acting metabolite of ibogaine) to keep cravings at bay and elevate your mood in the critical weeks following treatment.

Integration: Healing in Playa del Carmen

Ibogaine resets the brain, but true recovery requires integrating that reset into your mind and body. The days between your doses and the days following your final treatment are crucial.

We utilize the natural beauty and therapeutic environment of Playa del Carmen, Mexico, to help you reconnect with your pre-addictive self. Your personalized integration program includes:

• Psychotherapy: Daily integration sessions with our specialized therapists to unpack the insights gained during your flood doses.

• Nature Excursions: Guided trips to swim in the crystal-clear, ancient waters of local cenotes (natural limestone sinkholes) and relaxing beach trips to ground your nervous system.

• Cultural Exploration: Guided visits to historic Mayan ruins, fostering a sense of awe and connection to the world around you.

• Mind-Body Wellness: Gentle yoga and meditation sessions designed specifically to help your body process the physical changes and release stored trauma.

Peer-Reviewed Efficacy: What the Science Says

The clinical success of ibogaine in treating opioid use disorder (OUD) is well-documented in peer-reviewed literature. Unlike traditional Medication-Assisted Treatment (MAT), which only abates dependence, ibogaine actively disrupts the neurological mechanisms of addiction.

• Rapid Withdrawal Elimination: A landmark study published in the American Journal of Drug and Alcohol Abuse analyzed subjects with severe opioid dependence (70% of whom used oxycodone at high doses). The study found that Subjective Opioid Withdrawal Scale (SOWS) scores dropped significantly within hours of ibogaine administration, with withdrawal symptoms effectively neutralized.

• Long-Term Abstinence: In the same study, 50% of the participants reported complete abstinence from all opioids at the 1-month post-treatment follow-up. Drug use scores remained significantly improved from baseline for up to 12 months.

• Psychological Relief: Observational studies published by the Multidisciplinary Association for Psychedelic Studies (MAPS) and the Journal of Psychedelic Studies confirm that ibogaine treatment results in profound, long-term reductions in depression and anxiety—two of the primary drivers of oxycodone relapse.

Clinical Fact: Ibogaine and its derivative, noribogaine, are the only known treatments that consistently and immediately reduce both the physical withdrawal symptoms of opioid addiction and the psychological cravings simultaneously, without requiring long-term daily maintenance medications.

Explore Our Specialized Treatment Protocols

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